Liranaftate - CISMeF

Preferred Label : Liranaftate;

NCIt synonyms : (6-Methoxy-2-pyridinyl)methylcarbamothioic acid O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester;

NCIt definition : A thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is essential for cell membrane integrity. By preventing ergosterol synthesis and causing accumulation of squalene, this agent increases cell membrane permeability, cell leakage and eventually cell lysis.;

UNII : 5253IGO5X3;

InChIKey : VPHPQNGOVQYUMG-UHFFFAOYSA-N;

CAS number : 88678-31-3;

Drug name : Zefnart;

Molecule name : M-732;

Chemical formula : C18H20N2O2S;

Details

Origin ID

C66019;

UMLS CUI

C1173390;

Currated CISMeF NLP mapping
- liranaftate [MeSH concept]
- liranaftate [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- liranaftate [ATC Code]
- liranaftate [MeSH concept]
- liranaftate [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- liranaftate [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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