Levocetirizine

Preferred Label : Levocetirizine;

NCIt definition : A third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.;

UNII : 6U5EA9RT2O;

InChIKey : ZKLPARSLTMPFCP-OAQYLSRUSA-N;

CAS number : 130018-77-8;

Chemical formula : C21H25ClN2O3;

Details

Origin ID

C66008;

UMLS CUI

C1174893;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Levocetirizine (substance) [SNOMED CT concept]
- Product containing levocetirizine (medicinal product) [SNOMED CT concept]
- levocetirizine [ATC Code]
- levocetirizine [Substance BNPC]
- levocetirizine [MeSH Supplementary Concept]
- levocetirizine [MeSH concept]
Validated automatic mappings to BTNT
- levocetirizine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Levocetirizine Dihydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Levocetirizine Dihydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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