Preferred Label : Isoflurane;
NCIt synonyms : 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether; 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane;
NCIt definition : A fluorinated ether with general anesthetic and muscle relaxant activities. Although
the exact mechanism of action has not been established, inhaled isoflurane, appears
to act on the lipid matrix of the neuronal cell membrane, which results in disruption
of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter
gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory
neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic
excitatory transmission by increasing glutamate re-uptake, and potentiate glycine
receptor activity, which decreases motor function. In addition, isoflurane may alter
certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6,
IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway,
which may affect immune responses during surgery.;
UNII : CYS9AKD70P;
InChIKey : PIWKPBJCKXDKJR-UHFFFAOYSA-N;
CAS number : 26675-46-7;
Drug name : Forane; Isoflo; Aerrane;
Chemical formula : C3H2ClF5O;
ChEBI ID : CHEBI:6015;
Origin ID : C65978;
UMLS CUI : C0022180;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
