Preferred Label : Incadronic Acid;
NCIt synonyms : ((Cycloheptylamino)methylene)diphosphonic Acid;
NCIt definition : A third-generation amino-bisphosphonate with anti-resorptive activity. Although the
exact mechanism of action has yet to be fully elucidated, incadronic acid binds to
and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast
resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase,
an enzyme that plays an important role in the mevalonate pathway. This inhibits the
formation of isoprenoids that are essential for protein prenylation. This prevents
farnesylation and geranylgeranylation of proteins essential for osteoclast function,
thereby leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated
bone resorption, incadronic acid prevents bone destruction.;
UNII : G5C4M8847E;
InChIKey : LWRDQHOZTAOILO-UHFFFAOYSA-N;
CAS number : 124351-85-5;
Molecule name : YM175;
Chemical formula : C8H19NO6P2;
Origin ID : C65906;
UMLS CUI : C1881172;
Semantic type(s)
- concept_is_in_subset
