NCIt definition : A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor
activity. A weak base, ilaprazole accumulates in the acidic environment of the secretory
canaliculus of the gastric parietal cell where it is converted to an active sulfenamide
form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton
pump hydrogen-potassium adenosine triphosphatase (H /K ATPase), thereby inhibiting
the pump's activity and the parietal cell secretion of H ions into the gastric lumen,
the final step in gastric acid production.;