NCIt definition : A third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic
activities. Ibandronic acid binds to and adsorbs onto the surface of hydroxyapatite
crystals in the bone matrix, thereby preventing osteoclast resorption. This agent
also inhibits farnesyl pyrophosphate synthase, an enzyme involved in the mevalonate
pathway. Inhibition of this enzyme prevents the formation of isoprenoids, thereby
leading to a reduction in the farnesylation and geranylgeranylation of signaling proteins
of G protein-coupled signaling, and, eventually, inducing apoptosis of osteoclasts.
By inhibiting osteoclast-mediated bone resorption, ibandronic acid increases bone
mineral density, decreases bone remodeling and turnover, as well as reduces bone pain.;