Forasartan - CISMeF

Preferred Label : Forasartan;

NCIt synonyms : 5-((3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl)-2-(2-(1H-tetrazol-5-yl)phenyl)pyridine;

NCIt definition : A nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan selectively competes with angiotensin II for the binding of the angiotensin II (AT1) receptor subtype 1 in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex. This blocks the effects of aldosterone leading to an increase in sodium excretion and water and eventually a reduction in plasma volume and blood pressure.;

UNII : 065F7WPT0B;

InChIKey : YONOBYIBNBCDSJ-UHFFFAOYSA-N;

CAS number : 145216-43-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 145216-43-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SC 52458;

Chemical formula : C23H28N8;

Details

Origin ID

C65749;

UMLS CUI

C0250070;

Currated CISMeF NLP mapping
- forasartan [MeSH concept]
- forasartan [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- forasartan [MeSH concept]
- forasartan [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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