NCIt definition : A quinazolinone sulphonamide-based diuretic, structurally related to metolazone, with
thiazide-like activity. As a thiazide-like diuretic, fenquizone acts by blocking reabsorption
of sodium in the proximal tubule and the ascending branch of the loop of Henle. This
causes an increase in diuresis with the elimination of chloride and sodium.;