Febuxostat - CISMeF

Preferred Label : Febuxostat;

NCIt synonyms : 2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic Acid;

NCIt definition : An orally available, non-purine inhibitor of xanthine oxidase with uric acid lowering activity. Upon oral administration, febuxostat selectively and noncompetitively inhibits the activity of xanthine oxidase, an enzyme that converts oxypurines, including hypoxanthine and xanthine, into uric acid. By inhibiting xanthine oxidase, uric acid production is reduced and serum uric acid levels are lowered. Febuxostat may provide protection against acute renal failure caused by the excessive release of uric acid that occurs upon massive tumor cell lysis resulting from the treatment of some malignancies.;

UNII : 101V0R1N2E;

InChIKey : BQSJTQLCZDPROO-UHFFFAOYSA-N;

CAS number : 144060-53-7;

Drug name : Uloric; Adenuric;

Molecule name : TMX 67;

Chemical formula : C16H16N2O3S;

ChEBI ID : CHEBI:31596;

PubMed : 16339094;

Details

Origin ID

C65629;

UMLS CUI

C0249529;

CISMeF manual mappings
- Febuxostat [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Febuxostat [MeSH Descriptor]
- Febuxostat (substance) [SNOMED CT concept]
- Product containing febuxostat (medicinal product) [SNOMED CT concept]
- febuxostat [ATC Code]
- febuxostat [Substance BNPC]
- febuxostat [International Nonproprietary Name]
- febuxostat [MeSH concept]
Validated automatic mappings to BTNT
- febuxostat [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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