Entecavir - CISMeF

Preferred Label : Entecavir;

NCIt synonyms : 9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)Guanine Monohydrate; ETV; 6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)- Monohydrate;

NCIt definition : A synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.;

UNII : 5968Y6H45M;

InChIKey : YXPVEXCTPGULBZ-WQYNNSOESA-N;

CAS number : 209216-23-9;

Drug name : Baraclude;

Molecule name : BMS-200475-01; SQ-34676;

Chemical formula : C12H15N5O3.H2O;

ChEBI ID : CHEBI:59902;

Details

Origin ID

C65513;

UMLS CUI

C0971023;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Entecavir [LOINC component]
- Entecavir (substance) [SNOMED CT concept]
- Product containing entecavir (medicinal product) [SNOMED CT concept]
- entecavir [ATC Code]
- entecavir [MeSH concept]
- entecavir [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- entecavir [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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