Ebselen - CISMeF

Preferred Label : Ebselen;

NCIt definition : A organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H /K -ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.;

UNII : 40X2P7DPGH;

InChIKey : DYEFUKCXAQOFHX-UHFFFAOYSA-N;

CAS number : 60940-34-3;

Chemical formula : C13H9NOSe;

Details

Origin ID

C65503;

UMLS CUI

C0058903;

Currated CISMeF NLP mapping
- ebselen [MeSH concept]
- ebselen [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ebselen [MeSH concept]
- ebselen [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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