Difenoxin - CISMeF

Preferred Label : Difenoxin;

NCIt synonyms : 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid;

NCIt definition : A phenylpiperidine with antidiarrheal activity and an active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibiting the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects.;

UNII : 3ZZ5BJ9F2Q;

InChIKey : UFIVBRCCIRTJTN-UHFFFAOYSA-N;

CAS number : 28782-42-5;

Molecule name : McN-JR 15,403-11;

Chemical formula : C28H28N2O2;

ChEBI ID : CHEBI:4534;

Details

Origin ID

C65381;

UMLS CUI

C0057981;

Automatic exact mappings (from CISMeF team)
- Difenoxin [ICHI extension code]
- Difenoxin (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Difenoxin [ICD-11 Extension code]
- difenoxin [MeSH concept]
- difenoxin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Difenoxin [ICD-11 Extension code]
- Difenoxin (substance) [SNOMED CT concept]
- difenoxin [ATC Code]
- difenoxin [MeSH concept]
- difenoxin [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- difenoxin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Difenoxin Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Difenoxin Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients