NCIt definition : A benzothiadiazide belonging to the class of thiazide diuretics. Cyclothiazide is
indicated as adjunctive therapy in edema and in the treatment of hypertension. In
addition, this agent is capable of inhibiting rapid desensitization of the ionotropic
alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors,
thereby potentiating glutamate responses which may induce seizures activity. Cyclothiazide
was also found to inhibit gamma-aminobutyric acid (GABA)-A receptors.;