Clioquinol - CISMeF

Preferred Label : Clioquinol;

NCIt synonyms : Iodochlorohydroxyquinoline; 5-Chloro-7-iodo-8-hydroxyquinoline; 5-Chloro-7-iodo-quinolin-8-ol;

NCIt definition : An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors.;

UNII : 7BHQ856EJ5;

InChIKey : QCDFBFJGMNKBDO-UHFFFAOYSA-N;

CAS number : 130-26-7;

Drug name : Mycoquin;

Molecule name : AI3-16451;

Chemical formula : C9H5ClINO;

NSC code : 3531;

Details

Origin ID

C65337;

UMLS CUI

C0021978;

See also inter- (CISMeF)
- Product containing clioquinol (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5-Chloro-7-iodo-quinolinol (product) [Inactive SNOMED CT concept]
- Clioquinol [ICD-11 Extension code]
- Clioquinol (substance) [SNOMED CT concept]
- Product containing clioquinol (medicinal product) [SNOMED CT concept]
- clioquinol [ATC Code]
- clioquinol [ATC Code]
- clioquinol [ATC Code]
- clioquinol [ATC Code]
- clioquinol [ATC Code]
- clioquinol [Substance BNPC]
- clioquinol [MeSH concept]
- clioquinol [MeSH Descriptor]
- clioquinol [SNOMED Notion]
Validated automatic mappings to BTNT
- clioquinol [ATC Code]
- clioquinol [ATC Code]
- clioquinol [ATC Code]
- clioquinol [ATC Code]
- clioquinol [ATC Code]
chemical_or_drug_has_physiologic_effect
- Ion Transport Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients