Preferred Label : Chlorotrianisene;
NCIt synonyms : Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy-;
NCIt definition : An orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative
and selective estrogen receptor modulator (SERM), with predominantly estrogenic but
also antiestrogenic activities. Upon administration, chlorotrianisene binds to estrogen
receptors (ER) and, depending on the responsive target cells, either activates or
blocks ER activity. This modulates the expression of ER-responsive genes in a tissue-specific
manner. This agent may increase bone mineral density, modify the lipid profile and
ameliorate vasomotor symptoms. Chlorotrianisene inhibits the pituitary secretion of
the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
through a negative feedback mechanism.;
UNII : 6V5034L121;
InChIKey : BFPSDSIWYFKGBC-UHFFFAOYSA-N;
CAS number : 569-57-3;
Chemical formula : C23H21ClO3;
NSC code : 10108;
ChEBI ID : CHEBI:3641;
Origin ID : C65320;
UMLS CUI : C0008275;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
