Cerivastatin - CISMeF

Preferred Label : Cerivastatin;

NCIt definition : A synthetic lipid-lowering agent. Cerivastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent.;

UNII : AM91H2KS67;

InChIKey : SEERZIQQUAZTOL-ANMDKAQQSA-N;

CAS number : 145599-86-6;

Chemical formula : C26H34FNO5;

ChEBI ID : CHEBI:3558;

Details

Origin ID

C65308;

UMLS CUI

C0528023;

See also inter- (CISMeF)
- Product containing cerivastatin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cerivastatin (substance) [SNOMED CT concept]
- Product containing cerivastatin (medicinal product) [SNOMED CT concept]
- cerivastatin [ATC Code]
- cerivastatin [MeSH Supplementary Concept]
- cerivastatin [MeSH concept]
Validated automatic mappings to BTNT
- cerivastatin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Cerivastatin Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Cerivastatin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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