NCIt definition : The hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam
cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding
proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan.
By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell
wall synthesis is halted.;