" /> Candesartan - CISMeF





Preferred Label : Candesartan;

NCIt synonyms : 2-Ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-benzoimidazole-4-carboxylic Acid;

NCIt definition : A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. Candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.;

UNII : S8Q36MD2XX;

InChIKey : HTQMVQVXFRQIKW-UHFFFAOYSA-N;

CAS number : 139481-59-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 139481-59-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C24H20N6O3;

ChEBI ID : CHEBI:3347;

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22/05/2024


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