Preferred Label : Calcifediol;
NCIt definition : An orally available synthetic form of the calcitriol prohormone calcifediol (25-hydroxyvitamin
D), which can be used for vitamin D supplementation, and with potential immunomodulating
activity. Upon oral administration, calcifediol is taken up by the body and converted,
in the kidneys, to the active form calcitriol (1,25-dihydroxyvitamin D or 1,25(OH)2D).
This form increases and normalizes vitamin D plasma levels, which, in turn, regulates
calcium plasma levels, and normalizes elevated parathyroid hormone (PTH) levels by
suppressing both PTH synthesis, and secretion. Vitamin D modulates and enhances the
innate and adaptive immune responses. This may improve unregulated inflammation and
prevents the production of pro-inflammatory cytokines. Specifically, vitamin D binds
to its receptor vitamin D receptor (VDR) which is widely expressed on immune cells
and epithelial cells. This stimulates neutrophils, macrophages, and natural killer
(NK) cells, and activates epithelial cells to produce antimicrobial peptides (AMPs).
In addition, upon infection, vitamin D promotes the migration of myeloid dendritic
cells (mDCs) to lymphoid organs where they activate B- and T-lymphocytes.;
UNII : P6YZ13C99Q;
InChIKey : WRLFSJXJGJBFJQ-WPUCQFJDSA-N;
CAS number : 63283-36-3;
Chemical formula : C27H44O2.H2O;
Origin ID : C65278;
UMLS CUI : C0006657;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
