Bromfenac - CISMeF

Preferred Label : Bromfenac;

NCIt definition : A nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).;

UNII : 864P0921DW;

InChIKey : ZBPLOVFIXSTCRZ-UHFFFAOYSA-N;

CAS number : 91714-94-2;

Chemical formula : C15H12BrNO3;

ChEBI ID : CHEBI:240107;

Details

Origin ID

C65271;

UMLS CUI

C0054094;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Bromfenac (substance) [SNOMED CT concept]
- Product containing bromfenac (medicinal product) [SNOMED CT concept]
- bromfenac [ATC Code]
- bromfenac [MeSH concept]
- bromfenac [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- bromfenac [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Bromfenac Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Bromfenac Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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