Preferred Label : Brivaracetam;
NCIt synonyms : 1-Pyrrolidineacetamide, alpha-ethyl-2-oxo-4-propyl-, (alphaS,4R)-;
NCIt definition : An orally bioavailable levetiracetam derivative, with anticonvulsant activity. Although
the exact mechanism through which brivaracetam exerts its effects is not fully known,
this agent targets and binds to synaptic vesicle protein 2A (SV2A) in the brain. This
prevents synaptic vesicle exocytosis and the synaptic release of certain, as of yet
not fully known, excitatory neurotransmitters. This may inhibit impulse conduction
across synapses, decrease neuronal (hyper-)excitability, and may modulate epileptogenesis.
SV2A, a membrane glycoprotein present in neuronal synaptic vesicles, plays a key role
in action potential-induced neurotransmitter release in the brain.;
UNII : U863JGG2IA;
InChIKey : MSYKRHVOOPPJKU-BDAKNGLRSA-N;
CAS number : 357336-20-0;
Drug name : Briviact;
Molecule name : UCB34714;
Chemical formula : C11H20N2O2;
Origin ID : C65270;
UMLS CUI : C1699861;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
