NCIt definition : A sulfonamide triptan with extracerebral, intracranial vasoconstrictor activity. Almotriptan
selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central
nervous system (CNS), thereby causing extracerebral, intracranial blood vessel constriction.
This may lead to pain relief from vascular headaches. Almotriptan may also relieve
vascular headaches by preventing the release of vasoactive neuropeptides from perivascular
trigeminal axons in the dura mater during a migraine, by reducing extravasation of
plasma proteins, and by decreasing the release of other mediators of inflammation
from the trigeminal nerve.;