NCIt synonyms : Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy
chain), disulfide with human monoclonal D2E7 light chain, dimer; Adalimumab Biosimilar ABP 501;
NCIt definition : A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha
(TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds
to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors
and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine,
is upregulated in various autoimmune diseases.;