NCIt definition : A cell-based vaccine comprised of prostate cancer cells transduced with an adenoviral
vector encoding human RTVP-1 (AdRTVP-1), with potential antineoplastic and immunostimulating
activities. RTVP-1, also referred to as glioma pathogenesis-related protein 1 (GLIP1),
is down-regulated in prostate tumors. Regulated by tumor suppressor p53, the expression
of RTVP-1 functions as a tumor suppressor, and is abundant in normal human prostate
epithelial cells as well as in differentiated macrophages. Administration of this
vaccine leads to an induction of apoptosis through the expression of RTVP-1 and results
in a reduction in cellular proliferation in prostate cancer cells. In addition, this
cancer-cell based vaccine may induce a cytotoxic T lymphocyte (CTL) response against
prostate specific tumor associated antigens, resulting in an immune-mediated prostate
cancer cell death. Furthermore, RTVP-1 stimulates CTL and natural killer (NK) cell
activities.;