Preferred Label : Apoptosis Inducer MPC-2130;
NCIt definition : A broad-acting, apoptosis-inducing, small molecule with potential antineoplastic activity.
Although the exact mechanism of action has yet to be fully elucidated, apoptosis inducer
MPC-2130 exhibits proapoptotic activities in tumor cells, including membrane phosphatidylserine
externalization, release of cytochrome C from mitochondria, caspase activation, cell
condensation, and DNA fragmentation. In addition, because this agent is not a substrate
for several types of multidrug resistance (MDR) ABC superfamily transporters, such
as P-glycoprotein 1 (MDR-1), multidrug resistance-associated protein 1 (MRP1), and
breast cancer resistance protein 1 (BCRP1/ABCG2), it may be useful in treating MDR
tumors that express these particular MDR efflux pumps.;
Molecule name : MPC-2130;
Origin ID : C64781;
UMLS CUI : C1832002;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
