NCIt synonyms : PORxin 302; Pore-forming Protein (Synthetic Proaerolysin) Fusion Protein with Prostate-specific
Antigen (Human); PRX302;
NCIt definition : A targeted prodrug consisting of a recombinant modified form of the Aeromonas protoxin,
proaerolysin (PA), bearing a prostate-specific protease cleavage site, with potential
antineoplastic activity. When injected directly into the prostate, topsalysin is hydrolyzed
to the active toxin aerolysin by the serine protease prostate specific antigen (PSA),
a protein overexpressed by prostate cancers and prostate cells in hyperplastic prostatic
tissue. Aerolysin molecules then oligomerize to form ring-like heptamers that are
incorporated into the lipid bilayers of cell membranes, forming large membrane channels
and resulting in the leakage of cellular contents and lysis of PSA-expressing prostate
cells.;