" /> Topsalysin - CISMeF





Preferred Label : Topsalysin;

NCIt synonyms : PORxin 302; Pore-forming Protein (Synthetic Proaerolysin) Fusion Protein with Prostate-specific Antigen (Human); PRX302;

NCIt definition : A targeted prodrug consisting of a recombinant modified form of the Aeromonas protoxin, proaerolysin (PA), bearing a prostate-specific protease cleavage site, with potential antineoplastic activity. When injected directly into the prostate, topsalysin is hydrolyzed to the active toxin aerolysin by the serine protease prostate specific antigen (PSA), a protein overexpressed by prostate cancers and prostate cells in hyperplastic prostatic tissue. Aerolysin molecules then oligomerize to form ring-like heptamers that are incorporated into the lipid bilayers of cell membranes, forming large membrane channels and resulting in the leakage of cellular contents and lysis of PSA-expressing prostate cells.;

UNII : LSA9D0A43Q;

CAS number : 917121-25-6;

Molecule name : PSA-PAH1; PRX 302;

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31/05/2025


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