Preferred Label : Mycobacterial Cell Wall-DNA Complex;
NCIt synonyms : MCC;
NCIt definition : A proprietary preparation of mycobacterial DNA oligonucleotides embedded in mycobacterial
cell wall fragments derived from cultures of Mycobacterium phlei, with potential immunomodulatory
and antineoplastic activities. DNA oligonucleotides in the mycobacterial cell wall-DNA
complex (MCC) are capable of inducing apoptosis by increasing BAX protein levels,
releasing cytochrome C from mitochondria, and activating caspase-3 and -7. This leads
to the cleavage of poly (ADP-ribose) polymerase and the release of nuclear matrix
proteins (NuMA). In addition to its pro-apoptotic effect, MCC activates monocytes
and macrophages to produce various cytokines, including interleukin 6 (IL-6), IL-8,
IL-12, IL-18, and tumor necrosis factor alpha (TNF-a). This leads to an activation
of natural killer cells and cytotoxic T lymphocytes and to interferon gamma (INF-g)
synthesis, thereby attaining an anti-angiogenic effect.;
Origin ID : C64765;
UMLS CUI : C1832020;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
