Isavuconazole - CISMeF

Preferred Label : Isavuconazole;

NCIt definition : A water-soluble triazole prodrug with broad-spectrum antifungal activity. Isavuconazole is absorbed easily, given either orally or intravenously, and is hydrolyzed to its active moiety BAL4815 by plasma esterases. BAL4815 inhibits fungal cytochrome P450 lanosterol 14-alpha-demethylase (CYP51) that catalyzes the conversion of lanosterol to ergosterol, an important component of the fungal cell membrane. Enzyme inhibition by this agent leads to a decrease in ergosterol pool and therefore disturbs synthesis of fungal cell membrane, thereby increasing cell membrane permeability and promoting loss of essential intracellular elements. This ultimately causes fungal cell lysis and death.;

UNII : 60UTO373KE;

InChIKey : DDFOUSQFMYRUQK-RCDICMHDSA-N;

CAS number : 241479-67-4;

Molecule name : BAL8557;

Chemical formula : C22H17F2N5OS;

Détails

Origin ID

C64543;

UMLS CUI

C1832021;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Isavuconazole [LOINC component]
- Isavuconazole (substance) [SNOMED CT concept]
- isavuconazole [ATC Code]
- isavuconazole [MeSH Supplementary Concept]
- isavuconazole [MeSH concept]
Validated automatic mappings to BTNT
- isavuconazole [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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