Mediastinal Embryonal Carcinoma

Preferred Label : Mediastinal Embryonal Carcinoma;

NCIt synonyms : Embryonal Carcinoma of the Mediastinum; Embryonal Carcinoma of Mediastinum;

NCIt definition : An extragonadal malignant germ cell tumor that arises from the mediastinum and is composed of primitive large cells with clear or granular cytoplasm forming solid, glandular, or papillary patterns. It usually affects young males. It manifests with respiratory distress, thoracic or shoulder pain, fever, cough, superior vena cava syndrome, or hoarseness.;

Neoplastic status : Malignant;

Details

Origin ID

C6441;

UMLS CUI

C1334652;

Disease excludes abnormal cell
- Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus [NCIt concept]
- Neoplastic Sex Cord-Stromal Cell [NCIt concept]
Disease may have findings
- Chest Pain [NCIt concept]
- Cough [NCIt concept]
- Fever [NCIt concept]
- Hoarseness [NCIt concept]
- Multilocular Thymic Cyst [NCIt concept]
- Respiratory Distress [NCIt concept]
- Superior Vena Cava Syndrome [NCIt concept]
Excludes anatomical site(s)
- Gonad [NCIt concept]
- Neck [NCIt concept]
Has associated anatomic sites
- Mediastinum [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Has cytogenetic abnormalities
- i(12p) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Malignant Germinomatous Cells Present [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Large Germ Cell with Abundant Cytoplasm [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Germ Cell [NCIt concept]
disease_has_finding
- Geographic Necrosis [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Pseudoglandular Pattern [NCIt concept]
- Pseudopapillary Pattern [NCIt concept]
disease_has_normal_cell_origin
- Germ Cell [NCIt concept]
disease_has_normal_tissue_origin
- Germinal Layer [NCIt concept]
disease_has_primary_anatomic_site
- Mediastinum [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 12p [NCIt concept]
- i(12p) [NCIt concept]

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