Preferred Label : 2-Hydroxyestrone;
NCIt synonyms : Estra-1,3,5(1)-Trien-17-One, 2,3-Dihydroxy-; 1,3,5(10)-Estratrien-2,3-diol-17-one; 2-OHE1; 2-Hydroxyestrone; Catecholestrone; 2-OHE(1);
NCIt definition : A metabolite formed during the catabolism of estrone by the liver through the hydroxylation
of the carbon at position 2 by cytochrome P450 (CYP) enzymes, including CYP1A1 and
1A2, with potential anticarcinogenic activity. The mechanism of action for the antitumor
activity of 2-hydroxyestrone is not known but this metabolic product has minimal estrogenic
activity compared to the parent compound and other estrone metabolites. Additionally,
O-methylation of this compound produces 2-methoxyestradiol (2-MeOE2), which is a potent
inhibitor of both cell proliferation and angiogenesis.;
UNII : UQS3A06ILY;
InChIKey : SWINWPBPEKHUOD-JPVZDGGYSA-N;
CAS number : 362-06-1;
Chemical formula : C18H22O3;
ChEBI ID : CHEBI:1156;
Codes from synonyms : 20523;
Origin ID : C63947;
UMLS CUI : C0046200;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
