Caffeic Acid Phenethyl Ester

Preferred Label : Caffeic Acid Phenethyl Ester;

NCIt synonyms : 2-Phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoate; 3-(3,4-Dihydroxyphenyl)-2-propenoic Acid, 2-Phenylethyl Ester; CAPE;

NCIt definition : The phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, caffeic acid phenethyl ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).;

UNII : G960R9S5SK;

InChIKey : SWUARLUWKZWEBQ-VQHVLOKHSA-N;

CAS number : 104594-70-9;

Chemical formula : C17H16O4;

Codes from synonyms : 09056;

Details

Origin ID

C63756;

UMLS CUI

C0054434;

Currated CISMeF NLP mapping
- Cape (physical object) [SNOMED CT concept]
- caffeic acid phenethyl ester [MeSH concept]
- caffeic acid phenethyl ester [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- caffeic acid phenethyl ester [MeSH concept]
- caffeic acid phenethyl ester [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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