Preferred Label : Hydroxytyrosol;
NCIt synonyms : 3,4-DHPEA; 4-(2-Hydroxyethyl)-1,2-benzenediol; 2-(3,4-Dihydroxyphenyl)ethanol; 3 4-Dihydroxyphenylethanol;
NCIt related terms : 3,4-Dihydroxyphenylethanol;
NCIt definition : A phenolic phytochemical naturally occurring in extra virgin olive oil, with potential
antioxidant, anti-inflammatory and cancer preventive activities. Although the mechanisms
of action through which hydroxytyrosol exerts its effects have yet to be fully determined,
this agent affects the expression of various components of the inflammatory response,
possibly through the modulation of the nuclear factor-kappa B (NF-kB) pathway. The
effects include the modulation of pro-inflammatory cytokines, such as the inhibition
of interleukin-1alpha (IL-1a), IL-1beta, IL-6, IL-12, and tumor necrosis factor-alpha
(TNF-a); increased secretion of the anti-inflammatory cytokine IL-10; inhibition of
the production of certain chemokines, such as C-X-C motif chemokine ligand 10 (CXCL10/IP-10),
C-C motif chemokine ligand 2 (CCL2/MCP-1), and macrophage inflammatory protein-1beta
(CCL4/MIP-1b); and inhibition of the expression of the enzymes inducible nitric oxide
synthase (iNOS/NOS2) and prostaglandin E2 synthase (PGES), which prevent the production
of nitric oxide (NO) and prostaglandin E (PGE2), respectively. In addition, hydroxytyrosol
is able to regulate the expression of other genes involved in the regulation of tumor
cell proliferation, such as extracellular signal-regulated and cyclin-dependent kinases.
Also, hydroxytyrosol scavenges free radicals and prevents oxidative DNA damage. This
induces apoptosis and inhibits proliferation in susceptible cancer cells.;
UNII : QEU0NE4O90;
InChIKey : JUUBCHWRXWPFFH-UHFFFAOYSA-N;
CAS number : 10597-60-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 10597-60-1
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G-SRS /a ;
Chemical formula : C8H10O3;
Codes from synonyms : 20100;
Origin ID : C63690;
UMLS CUI : C0243264;
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset