Mofarotene - CISMeF

Preferred Label : Mofarotene;

NCIt synonyms : Mofarontene; (E)-4-[2-[4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]phenoxy]ethyl]morpholine;

NCIt definition : An arotinoic acid derivative with a morpholine structure in the polar end group with differentiation inducing and antineoplastic activity. Like other retinoic acid agents, mofarotene binds to and activates retinoic acid receptors (RARs), thereby altering the expression of certain genes leading to cell differentiation and decreased cell proliferation in susceptible cells. In addition, this agent is able to inhibit melanoma cell motility.;

UNII : 8K3CVY8F8V;

InChIKey : OUQPTBCOEKUHBH-LSDHQDQOSA-N;

CAS number : 125533-88-2;

Molecule name : Ro 40-8757;

Chemical formula : C29H39NO2;

Codes from synonyms : 08948;

Details

Origin ID

C63667;

UMLS CUI

C0247161;

Currated CISMeF NLP mapping
- mofarotene [MeSH concept]
- mofarotene [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mofarotene [MeSH concept]
- mofarotene [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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