Preferred Label : Astaxanthin;
NCIt synonyms : Astaxanthine; (3S,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione;
NCIt definition : A natural and synthetic xanthophyll and nonprovitamin A carotenoid, with potential
antioxidant, anti-inflammatory and antineoplastic activities. Upon administration,
astaxanthin may act as an antioxidant and reduce oxidative stress, thereby preventing
protein and lipid oxidation and DNA damage. By decreasing the production of reactive
oxygen species (ROS) and free radicals, it may also prevent ROS-induced activation
of nuclear factor-kappa B (NF-kB) transcription factor and the production of inflammatory
cytokines such as interleukin-1beta (IL-1b), IL-6 and tumor necrosis factor-alpha
(TNF-a). In addition, astaxanthin may inhibit cyclooxygenase-1 (COX-1) and nitric
oxide (NO) activities, thereby reducing inflammation. Oxidative stress and inflammation
play key roles in the pathogenesis of many diseases, including cardiovascular, neurological,
autoimmune and neoplastic diseases.;
Alternative definition : CRCH: Carotenoid having a chemical structure similar to beta-carotene with hydroxyl
groups at the number 3 and 3' carbon atoms and carbonyl (C O) functions at the number
4 and 4' carbon atoms.;
UNII : 8XPW32PR7I;
InChIKey : MQZIGYBFDRPAKN-UWFIBFSHSA-N;
CAS number : 472-61-7;
Unit used : mcg;
Chemical formula : C40H52O4;
ChEBI ID : CHEBI:40968;
Codes from synonyms : 01235;
Origin ID : C63653;
UMLS CUI : C0052565;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
