Preferred Label : Minocycline-EDTA;
NCIt synonyms : Minocycline-Ethylenediaminetetraacetate; M-EDTA;
NCIt definition : A combination preparation containing minocycline, a broad-spectrum, semi-synthetic
tetracycline antibiotic, and ethylenediaminetetraacetate (EDTA) with antimicrobial
and anticoagulant activities. Minocycline exerts its bacteriostatic effect by binding
to the bacterial 30S ribosomal subunit and preventing binding of aminoacyl-tRNA to
the mRNA-ribosome complex during protein translation. This leads to an inhibition
of bacterial protein synthesis and consequently interferes with cell growth. EDTA,
a metal chelator, exerts its anticoagulant activity by binding to calcium, thereby
impeding the activity of calcium-dependent coagulation proteins. This leads to an
inhibition of thrombotic occlusion and prevention of bacterial colonization that could
occur upon clot formation.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of bacterial infections from
catheters (flexible tubes used to deliver fluids into or take fluids from the body).
It combines a drug used to treat infections with a drug that prevents blood clots.
It is a type of tetracycline antibiotic.;
Codes from synonyms : CDR0000546758; CDR0000528023;
Origin ID : C63545;
UMLS CUI : C1831960;
Semantic type(s)
- concept_is_in_subset
