HLA-DQ Antigen

Preferred Label : HLA-DQ Antigen;

NCIt definition : HLA-DQ antigen is a class of glycoproteins that consist of dimers of alpha and beta subunits, which are encoded by the polymorphic human genes HLA-DQA1 and HLA-DQB1, respectively. This protein complex is expressed primarily in lymphoid cells and function to present antigens for CD4 T lymphocytes. Certain HLA-DQ protein variants are associated with susceptibility to insulin-dependent diabetes mellitus and several autoimmune diseases.;

Details

Origin ID

C62792;

UMLS CUI

C0019761;

Automatic exact mappings (from CISMeF team)
- HLA-DQ [LOINC component]
- HLA-DQX antigen [MeSH Supplementary Concept]
- HLA-DQX antigen [MeSH concept]
Currated CISMeF NLP mapping
- HLA-DQ antigens [MeSH Descriptor]
- HLA-DQ antigens [MeSH concept]
- Human leukocyte antigen DQ (substance) [SNOMED CT concept]
- hla-dq antigen, nos [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- HLA-DQ [LOINC component]
- HLA-DQ antigens [MeSH concept]
- HLA-DQ antigens [MeSH Descriptor]
- Human leukocyte antigen DQ (substance) [SNOMED CT concept]
- hla-dq antigen, nos [SNOMED Notion]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- MHC Class II Gene [NCIt concept]
gene_product_expressed_in_tissue
- CD4-Positive T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- HLA Complex [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Immune System Process [NCIt concept]
- Immunoregulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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