Preferred Label : Liposomal Vinorelbine;
NCIt definition : A formulation of the semisynthetic vinca alkaloid, vinorelbine, encapsulated within
liposomes, with antineoplastic activity. Vinorelbine binds to tubulin and prevents
formation of the mitotic spindle, resulting in cell cycle arrest in metaphase. Like
other vinca alkaloids, vinorelbine may also interfere with the metabolism of nucleic
acids, lipids, amino acids, cAMP, and glutathione, as well as other biological processes
including calmodulin-dependent Ca2 -transport, ATPase activity, or cellular respiration.
Liposomal delivery of vinorelbine improves drug penetration into tumors and decreases
drug clearance, thereby increasing the duration of therapeutic effects while lowering
the toxicity profile.;
Origin ID : C62790;
UMLS CUI : C1831959;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
