Preferred Label : LMP2A-Specific Cytotoxic T-Lymphocytes;
NCIt synonyms : EBV-Specific Cytotoxic T-Lymphocytes; LMP2A-Specific CTL; LMP2A-Specific Cytotoxic T Lymphocytes;
NCIt definition : A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to Epstein-Barr
virus (EBV) latent membrane protein-2A (LMP2A), with potential antineoplastic activity.
T-lymphocytes are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient
adenovirus encoding EBV LMP2A. Subsequently, LMP2A-specific CTLs are exposed to EBV
infected cells transfected with adenovirus encoding LMP2A, thereby further stimulating
CTLs. Administered to patients with EBV-positive tumors, LMP2A-specific CTLs target
LMP2A-positive cells, resulting in cell lysis and inhibition of cancer cell proliferation.
EBV LMP2A may be expressed in various malignancies, including nasopharyngeal carcinoma
and Hodgkin and non-Hodgkin lymphomas.;
Origin ID : C62784;
UMLS CUI : C1328049;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
