NCIt definition : A preparation of allogeneic Epstein-Barr virus (EBV) specific cytotoxic T-lymphocytes
(CTL) with potential antineoplastic activity. Upon administration, the allogeneic
EBV-specific CTLs are either harvested from a donor with an EBV-positive tumor or
are donor CTLs activated against EBV-specific antigens ex vivo. Administration into
a patient exerts a CTL response against EBV-positive tumor cells or EBV-infected cells.
This results in cell lysis and inhibition of cancer cell proliferation. EBV, a ubiquitous
human herpes virus, is associated with various malignancies, including nasopharyngeal
carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas.;
Automatic exact mappings (from CISMeF team)