Synthetic Alkaloid PM00104

Preferred Label : Synthetic Alkaloid PM00104;

NCIt related terms : PM00104; PM-00104;

NCIt definition : A synthetic alkaloid compound, related to natural alkaloid compounds, found in molluscs (jorumycin) and sponges (renieramycins), with potential antineoplastic activity. PM00104 reversibly binds to DNA, thereby inducing cytotoxicity due to its interference with DNA replication, transcription, and translation processes. DNA binding by this agent does not trigger DNA damage checkpoint responses, hence PM00104 demonstrates a manageable and reversible cytotoxicity as part of its antitumor activity.;

UNII : C21EZR41AY;

CAS number : 308359-57-1;

Drug name : Zalypsis;

PubMed : 19584237;

Details

Origin ID

C62763;

UMLS CUI

C1568937;

Currated CISMeF NLP mapping
- PM 00104 [MeSH concept]
- PM 00104 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PM 00104 [MeSH concept]
- PM 00104 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]

Keyword's position in hierarchy(ies) :

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