Preferred Label : Clostridium Novyi-NT Spores;
NCIt synonyms : C. novyi-NT Spores;
NCIt definition : Spores of the bacterial strain Clostridium novyi-NT, the attenuated obligate anaerobic
C. novyi, with potential immunostimulating, bacteriolytic, and antineoplastic activities.
Upon intravenous administration, Clostridium novyi-NT spores germinate exclusively
in hypoxic tissue, such as avascular regions of tumors. Germination results in lysis
and destruction of surrounding viable tumor cells. Due to their anaerobic nature,
C. novyi-NT spores do not proliferate in oxygenated tumor regions. However, this agent
may stimulate the immune system to exert a cellular immune response, resulting in
additional killing of tumor cells not lysed by the bacteria, including those in the
well-oxygenated tumor area.;
Origin ID : C62762;
UMLS CUI : C1831945;
Semantic type(s)
- concept_is_in_subset
