Salsalate - CISMeF

Preferred Label : Salsalate;

NCIt synonyms : o-Salicylsalicylic Acid; Salicylsalicylic Acid; Benzoic Acid, 2-Hydroxy-, 2-Carboxyphenyl Ester;

NCIt related terms : Disalcid;

NCIt definition : An orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. As a prodrug, salsalate is hydrolyzed to salicylic acid which inhibits the expression of cyclooxygenase (COX) enzymes. This prevents the conversion of arachidonic acid into prostaglandin precursors and leads to decreased formation of prostaglandins that are involved in pain, fever and inflammation. In addition, salsalate appears to inhibit nuclear factor-kappa B (NF-kB), thereby preventing activation of the NF-kB-mediated pathway and the expression of genes involved in inflammation.;

UNII : V9MO595C9I;

InChIKey : WVYADZUPLLSGPU-UHFFFAOYSA-N;

CAS number : 552-94-3;

Drug name : Disalcid; Mono-Gesic; Salflex; Salsitab;

Chemical formula : C14H10O5;

NSC code : 49171;

Codes from synonyms : NSC0049171;

Details

Origin ID

C62636;

UMLS CUI

C0073983;

Automatic exact mappings (from CISMeF team)
- Salsalate [ICHI extension code]
Currated CISMeF NLP mapping
- Salsalate [ICD-11 Extension code]
- Salsalate (substance) [SNOMED CT concept]
- Sasapyrine [LOINC component]
- salicylsalicylic acid [MeSH concept]
- salicylsalicylic acid [MeSH Supplementary Concept]
- salsalate, nos [SNOMED Notion]
See also inter- (CISMeF)
- Product containing salsalate (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing salsalate (medicinal product) [SNOMED CT concept]
- Salsalate [ICD-11 Extension code]
- Salsalate (substance) [SNOMED CT concept]
- Sasapyrine [LOINC component]
- salicylsalicylic acid [MeSH concept]
- salicylsalicylic acid [MeSH Supplementary Concept]
- salsalate [ATC Code]
- salsalate, nos [SNOMED Notion]
Validated automatic mappings to BTNT
- salsalate [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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