2-Methoxyestradiol Nanocrystal Colloidal Dispersion

Preferred Label : 2-Methoxyestradiol Nanocrystal Colloidal Dispersion;

NCIt synonyms : 2-Methoxyestradiol Nanocrystal Colloidal Dispersion;

NCIt definition : An orally bioavailable liquid formulation containing the small molecule 2-methoxyestradiol with potential antineoplastic activity. 2-Methoxyestradiol, a naturally occurring estradiol metabolite, exerts its antitumor effect by inhibiting endothelial cells as well as tumor cells through multiple mechanisms. This agent binds to tubulin and disrupts microtubule formation, thereby preventing mitosis and subsequent cellular proliferation. In addition, 2-methoxyestradiol induces caspase activation, resulting in cell cycle arrest in G2 phase and apoptosis in due course. This agent also down-regulates hypoxia inducible factor-one alpha (HIF-1a). The nanocrystal colloidal dispersion increases the absorption of 2-methoxyestradiol, thereby improving its bioavailability, which results in enhanced drug plasma levels.;

Drug name : Panzem NCD;

Détails

Origin ID

C62603;

UMLS CUI

C1831865;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of G2 Phase [NCIt concept]
- Negative Regulation of Mitosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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