Preferred Label : Maytansine;
NCIt synonyms : Maysanine; alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26],
16,18-pentaene-8,23-dione; L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,
5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)];
NCIt related terms : Alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,
22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione; L-Alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,
23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl
ester, [1S-(1R*,2S*, 3R*,5R*,6R*,16E,18E,20S*,21R*)]-; Maitansine; Maytansin;
NCIt definition : An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata.
Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule
assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits
cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04);
UNII : 14083FR882;
InChIKey : WKPWGQKGSOKKOO-RSFHAFMBSA-N;
CAS number : 35846-53-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 35846-53-8
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G-SRS /a ;
Chemical formula : C34H46ClN3O10;
NSC code : 153858;
Codes from synonyms : NSC0153858;
Origin ID : C626;
UMLS CUI : C0024975;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
