Preferred Label : CHP-NY-ESO-1 Peptide Vaccine IMF-001;
NCIt synonyms : Cholesteryl Pullulan-NY-ESO-1 Vaccine IMF-001; CHP-NY-ESO-1 Peptide Vaccine;
NCIt definition : A peptide cancer vaccine containing nanoparticles of cholesteryl hydrophobized pullulan
(CHP) complexed with the cancer-testis antigen NY-ESO-1 protein, with potential immunostimulating
and antineoplastic activities. Upon administration, CHP-NY-ESO-1 peptide vaccine IMF-001
may stimulate the host immune system to mount a humoral and cytotoxic T-cell response
against tumor cells expressing NY-ESO-1 antigen, resulting in tumor cell lysis. The
self-aggregating CHP, composed of a pullulan backbone and cholesterol branches, forms
stable colloidal nanoparticles in water. NY-ESO-1, an antigen found in normal testis,
is upregulated in various cancers, including bladder, breast, hepatocellular, melanoma,
and prostate cancers.;
Molecule name : IMF-001;
Origin ID : C62598;
UMLS CUI : C2987455;
Semantic type(s)
- concept_is_in_subset
- has_target
