Preferred Label : Bowen Disease of the Skin;
NCIt synonyms : Intraepidermal Squamous Cell Carcinoma, Bowen Type; Bowen's Disease of the Skin;
NCIt related terms : Bowen disease;
NCIt definition : A form of squamous cell carcinoma in situ. It is a distinct clinicopathological entity
and arises from the skin or the mucocutaneous junction. It affects predominantly white
males in their 6-8th decades of life. Exposed and non-exposed skin sites are equally
affected. UV damage and ingestion of inorganic arsenic may play a role in the development
of the disease. On the skin surface, it presents as a single or multiple erythematous,
scaly, keratotic patches or plaques. The clinical entity of erythroplasia of Queyrat
is regarded as Bowen disease of the penis and it presents as an asymptomatic, red,
circumscribed plaque. Morphologically, Bowen disease is characterized by the presence
of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous
cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal
basement membrane is intact. Complete surgical removal of the lesion may be curative.;
Alternative definition : NCI-GLOSS: A skin disease marked by scaly or thickened patches on the skin and often
caused by prolonged exposure to arsenic. The patches often occur on sun-exposed areas
of the skin and in older white men. These patches may become malignant (cancer).;
Neoplastic status : Malignant;
ICD-O code : 8081/2;
Codes from synonyms : CDR0000044251;
Origin ID : C62571;
UMLS CUI : C0006079;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Disease excludes abnormal cell
- Disease may have findings
- False automatic mappings
- Has associated anatomic sites
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_grade
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
- disease_mapped_to_gene
- pathogenesis_of_disease_involves_gene
