Preferred Label : Recombinant Parathyroid Hormone;
NCIt related terms : PARATHYROID HORMONE;
NCIt definition : A recombinant therapeutic agent that is identical or similar to an 84-amino-acid polypeptide
produced by the parathyroid gland which functions to maintain a constant concentration
of calcium ions (Ca2 ) in the extracellular fluid. In target tissues, parathyroid
hormone (PTH) binds to and activates the PTH receptor (PTHR), a cell surface G protein-coupled
receptor; there are two types of receptors, PTHR1 found in bone and the kidney and
PTHR2 found primarily in the central nervous system (CNS), pancreas, testis, and placenta.
Activation of PTHRs results in the activation of adenylyl cyclase and phospholipase
C in target tissue cells, which, depending upon the specific target tissue, results
in the enhancement of intestinal Ca2 absorption, mobilization of bone Ca2 , and renal
Ca2 reabsorption.;
UNII : N19A0T0E5J;
CAS number : 9002-64-6;
Origin ID : C62555;
UMLS CUI : C1882913;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
- has_target
