Preferred Label : 14C BMS-275183;
NCIt synonyms : [14C] BMS-275183; 14C BMS-275183;
NCIt definition : An orally bioavailable taxane compound, a C-4 methyl carbonate analogue of paclitaxel,
labeled with radioactive carbon 14, with potential antineoplastic and radioimaging
activities. BMS-275183 binds to tubulin and as a result inhibits microtubule disassembly
or assembly. This leads to cell cycle arrest at the G2/M phase, thereby resulting
in an inhibition of cell division and ultimately cell death. BMS-275183 may be useful
for treating multi-drug resistant tumors as it does not appear to be a substrate for
P-glycoprotein.;
Origin ID : C62553;
UMLS CUI : C1831856;
Semantic type(s)
- concept_is_in_subset
- has_target
