" /> Colloidal Gold-Bound Tumor Necrosis Factor - CISMeF





Preferred Label : Colloidal Gold-Bound Tumor Necrosis Factor;

NCIt synonyms : Colloidal Gold-Bound Recombinant Human Tumor Necrosis Factor; colloidal gold-bound TNF; colloidal gold-bound rhTNF;

NCIt related terms : Aurimmune; TNF-bound colloidal gold;

NCIt definition : A nanoparticle delivery system for recombinant human tumor necrosis factor (TNF) consisting of recombinant TNF bound to pegylated colloidal gold nanoparticles with potential antineoplastic activity. Upon intravenous administration, colloidal gold-bound recombinant human TNF travels through the bloodstream, avoiding immune detection and uptake by the reticuloendothelial system because of nanoparticle pegylation. Due to their size, the colloidal gold nanoparticles exit the circulatory system only at hyperpermeable tumor neovasculature sites; TNF then binds to and activates tumor cell TNF receptors, which may result in an increase in tumor cell apoptosis and a reduction in tumor cell proliferation. Compared to the administration of unbound TNF, colloidal gold-bound TNF may improve the efficacy and safety of TNF administration by delivering TNF specifically to tumor tissue.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Aurimmune is made in the laboratory by binding a cancer-killing protein called tumor necrosis factor (TNF) to the surface of very tiny particles of gold. These TNF-gold particles may kill cancer cells without harming healthy tissue.;

Drug name : Aurimmune;

Molecule name : CYT-6091;

Codes from synonyms : CDR0000539486; CDR0000539485; CDR0000518307;

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12/05/2024


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