NCIt definition : A stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione)
and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities.
Mimicking endogenous GSSG, glutathione disulfide NOV-002 acts as a competitive substrate
for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation
of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and
ER stress-induced apoptosis; S-glutathionylation may be stimulated by reactive oxygen
species (ROS) liberated by a glutathione disulfide NOV-002-induced increase in GGT
activity. Glutathione disulfide NOV-002 may also induce phosphorylation of proteins
such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation
and apoptosis. The cisplatin component of this agent does not provide an effective
therapeutic concentration of cisplatin in vivo.;
Currated CISMeF NLP mapping